Article
Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations.
Neurology - 12 Feb 2008
Chen-Plotkin A S, Yuan W, Anderson C, McCarty Wood E, Hurtig H I, Clark C M, Miller B L, Lee V M-Y, Trojanowski J Q, Grossman M, Van Deerlin V M
Abstract excerpt
BACKGROUND: Mutations in the LRRK2 gene are an important cause of familial and nonfamilial parkinsonism. Despite pleomorphic pathology, LRRK2 mutations are believed to manifest clinically as typical Parkinson disease (PD). However, most genetic screens have been limited to PD clinic populations. OBJECTIVE: To clinically characterize LRRK2 mutations in cases recruited from a spectrum of neurodegenerative diseases....
Topics
- Adult
- Aged
- Aged, 80 and over
- Aphasia, Primary Progressive
- Brain
- DNA Mutational Analysis
- Female
- Genetic Markers
- Genetic Predisposition to Disease
- Genetic Testing
- Genotype