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Article

Identifying Likely Transmission Pathways within a 10-Year Community Outbreak of Tuberculosis by High-Depth Whole Genome Sequencing.

PloS one - 1 Jan 2016

Outhred Alexander C, Holmes Nadine, Sadsad Rosemarie, Martinez Elena, Jelfs Peter, Hill-Cawthorne Grant A, Gilbert Gwendolyn L, Marais Ben J, Sintchenko Vitali

Abstract excerpt

BACKGROUND: Improved tuberculosis control and the need to contain the spread of drug-resistant strains provide a strong rationale for exploring tuberculosis transmission dynamics at the population level. Whole-genome sequencing provides optimal strain resolution, facilitating detailed mapping of potential transmission pathways. METHODS: We sequenced 22 isolates from a Mycobacterium tuberculosis cluster in New...

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PMID: 26938641
DOI: 10.1371/journal.pone.0150550
PMCID: PMC4777479

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