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Article

Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort.

Nature genetics - 1 Feb 2022

Qin Youwen, Havulinna Aki S, Liu Yang, Jousilahti Pekka, Ritchie Scott C, Tokolyi Alex, Sanders Jon G, Valsta Liisa, Brożyńska Marta, Zhu Qiyun, Tripathi Anupriya, Vázquez-Baeza Yoshiki, Loomba Rohit, Cheng Susan, Jain Mohit, Niiranen Teemu, Lahti Leo, Knight Rob, Salomaa Veikko, Inouye Michael, Méric Guillaume

Abstract excerpt

Human genetic variation affects the gut microbiota through a complex combination of environmental and host factors. Here we characterize genetic variations associated with microbial abundances in a single large-scale population-based cohort of 5,959 genotyped individuals with matched gut microbial metagenomes, and dietary and health records (prevalent and follow-up). We identified 567 independent SNP-taxon...

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Identifiers

PMID: 35115689
DOI: 10.1038/s41588-021-00991-z
PMCID: PMC9883041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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