Article
AMPK activation overcomes anti-EGFR antibody resistance induced by KRAS mutation in colorectal cancer.
Cell communication and signaling : CCS - 23 Jul 2020
Ye Hua, Liu Yi, Wu Kefeng, Luo Hui, Cui Liao
Abstract excerpt
BACKGROUND: Colorectal cancer (CRC) is associated with resistance to anti-epidermal growth factor receptor (EGFR) antibodies (both acquired and intrinsic), owing to the amplification or mutation of the KRAS oncogene. However, the mechanism underlying this resistance is incompletely understood. METHODS: DLD1 cells with WT (+/-) or KRAS G13D mutant allele were treated with different concentrations of Cetuximab...
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