AMP-kinase mediates adaptation of glioblastoma cells to conditions of the tumour microenvironment

Abstract excerpt

AMP-activated protein kinase (AMPK) is a central cellular energy sensor that regulates metabolic activity. We hypothesised that in glioblastoma (GB), AMPK plays a pivotal role in balancing metabolism under conditions of the tumour microenvironment, which is characterised by fluctuating and often low nutrient and oxygen availability. Impairment of this network could thus interfere with tumour progression. AMPK acti...

Topics

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• AMP-Activated Protein Kinases
• Autophagy in Disease and Therapy
• Cancer, Hypoxia, and Metabolism
• Casein Kinase II
• Cellular Senescence
• Cyclic AMP Response Element-Binding Protein
• Metabolism, Diabetes, and Cancer
• Pancreatic function and diabetes

Identifiers and source

Literature Corpus work

738b1fd3-b143-5c3c-ab25-b06b9e11d334

DOI

10.1101/2022.03.25.485624