Article
Macrophage/monocyte-specific deletion of Ras homolog gene family member A (RhoA) downregulates fractalkine receptor and inhibits chronic rejection of mouse cardiac allografts.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Mar 2017
Liu Yianzhu, Chen Wenhao, Wu Chenglin, Minze Laurie J, Kubiak Jacek Z, Li Xian C, Kloc Malgorzata, Ghobrial Rafik M
Abstract excerpt
BACKGROUND: The cellular and molecular mechanisms of chronic rejection of transplanted organs remain obscure; however, macrophages are known to play a critical role in the injury and repair of allografts. Among multiple factors influencing macrophage infiltration to allografts, the fractalkine chemokine (C-X3-C motif) ligand 1(CX3CL1)/chemokine (C-X3-C motif) receptor 1 (CX3CR1) signaling pathway and actin...
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