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Article

Self-Maintenance of Cardiac Resident Reparative Macrophages Attenuates Doxorubicin-Induced Cardiomyopathy Through the SR-A1-c-Myc Axis.

Circulation research - 14 Aug 2020

Zhang Hanwen, Xu Andi, Sun Xuan, Yang Yaqing, Zhang Lai, Bai Hui, Ben Jingjing, Zhu Xudong, Li Xiaoyu, Yang Qing, Wang Zidun, Wu Wei, Yang Di, Zhang Yongjie, Xu Yong, Chen Qi

Abstract excerpt

RATIONALE: Doxorubicin-induced cardiomyopathy (DiCM) is a primary cause of heart failure and mortality in cancer patients, in which macrophage-orchestrated inflammation serves as an essential pathological mechanism. However, the specific roles of tissue-resident and monocyte-derived macrophages in DiCM remain poorly understood. OBJECTIVE: Uncovering the origins, phenotypes, and functions of proliferative cardiac...

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Identifiers

PMID: 32466726
DOI: 10.1161/CIRCRESAHA.119.316428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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