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Article

Use of recombinase activation gene-2 deficient mice to ascertain the role of cellular and humoral immune responses in the development of chronic rejection.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Jul 2002

Sun Hong, Woodward Jennifer E, Subbotin Vladimir M, Kuddus Ruhul, Logar Alison J, Schaefer Adam T, Aitouche Abdelouahab, Rao Abdul S

Abstract excerpt

INTRODUCTION: Given its multifactorial etiology, the relative contribution of anti-donor cellular and humoral immune responses in the pathogenesis of chronic rejection is as yet ambiguous. We hypothesized that alloreactive T and B cells play a seminal role in the development of this lesion. METHODS: To address this hypothesis, RAG-2(-/-) mice were used as donors and recipients in a well-established murine model...

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Identifiers

PMID: 12100900
DOI: 10.1016/s1053-2498(02)00393-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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