Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endothelial Cells Require CD98 for Efficient Angiogenesis-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2016

Liao Zhongji, Cantor Joseph M

Abstract excerpt

OBJECTIVE: CD98 regulates integrin signaling and is critical for tumor cell proliferation. It is also expressed on endothelial cells (EC), but its role in angiogenesis is unclear. APPROACH AND RESULTS: We used specific genetic targeting and antibody blockade approaches to examine the function of CD98 in EC proliferation, blood vessel growth, and tumor angiogenesis. It is upregulated on angiogenic ECs, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis Inhibitors
Share to Human Umbilical Vein Endothelial Cells
Share to Integrins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanoma, Experimental

Share to Neovascularization, Physiologic

Share to Retinal Neovascularization

Share to Tumor Burden

Share to Vascular Endothelial Growth Factor Receptor-2

Source

Open in PubMed Open full text

Identifiers

PMID: 27687603
DOI: 10.1161/ATVBAHA.116.308335
PMCID: PMC5954993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endothelial Cells Require CD98 for Efficient Angiogenesis-Brief Report.PMID 27687603Read ↗

Understanding the Role of Endothelial Cells in Glioblastoma: Mechanisms and Novel TreatmentsSemantic proximity Read ↗

Endothelial cell malignancies: new insights from the laboratory and clinicSemantic proximity Read ↗

Roles of endothelial cell specific molecule‑1 in tumor angiogenesis (Review)Semantic proximity Read ↗

Tumor angiogenesis: molecular pathology, therapeutic targeting, and imaging.Semantic proximity Read ↗

Cross-Linking CD98 Promotes Integrin-like Signaling and Anchorage-independent GrowthSemantic proximity Read ↗

Endothelial-secreted Endocan activates PDGFRA and regulates vascularity and spatial phenotype in glioblastoma.Semantic proximity Read ↗

CD99 is a potential diagnostic and immunological biomarker in pan-cancerSemantic proximity Read ↗

Talin-dependent integrin activation is required for endothelial proliferation and postnatal angiogenesis.Semantic proximity Read ↗

CD98 modulates integrin beta1 function in polarized epithelial cells.Semantic proximity Read ↗

CD97, an adhesion receptor on inflammatory cells, stimulates angiogenesis through binding integrin counterreceptors on endothelial cells.Semantic proximity Read ↗

CD105 is important for angiogenesis: evidence and potential applications.Semantic proximity Read ↗

Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.