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Article

Cross-Linking CD98 Promotes Integrin-like Signaling and Anchorage-independent Growth

1 Aug 2002

Abstract excerpt

CD98, an early marker of T-cell activation, is an important regulator of integrin-mediated adhesion events. Previous studies suggest that CD98 is coupled to both cellular activation and transformation and is involved in the pathogenesis of viral infection, inflammatory disease, and cancer. Understanding of the molecular mechanisms underlying CD98 activity may have far-reaching practical applications in the...

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PMID: 12181350
DOI: 10.1091/mbc.01-11-0530

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