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Concomitant emergence of the antisense protein gene of HIV-1 and of the pandemic

28 Sept 2016

Abstract excerpt

Recent experiments provide sound arguments in favor of the in vivo expression of the AntiSense Protein (ASP) of HIV-1. This putative protein is encoded on the antisense strand of the provirus genome and entirely overlapped by the env gene with reading frame -2. The existence of ASP was suggested in 1988, but is still controversial, and its function has yet to be determined. We used a large dataset of ∼23,000...

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PMID: 27681623
DOI: 10.1073/pnas.1605739113

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