Covariation of amino acid substitutions in the HIV-1 envelope glycoprotein gp120 and the antisense protein ASP associated with coreceptor usage

Abstract excerpt

The tropism of the Human Immunodeficiency Virus type 1 (HIV-1) is determined by the use of either or both of the chemokine coreceptors CCR5 (R5) or CXCR4 (X4) for entry into the target cell. The ability of HIV-1 to bind R5 or X4 is determined primarily by the third variable loop (V3) of the viral envelope glycoprotein gp120. HIV-1 strains of pandemic group M contain an antisense gene termed asp , which overlaps...

Topics

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• Genotype
• HIV-1
• HIV Envelope Protein gp120
• HIV Infections
• Machine Learning
• Mutation
• RNA, Viral
• Viral Tropism

Identifiers and source

Literature Corpus work

3eff880c-2692-5313-8aee-0c6fc5f0c4f8

DOI

10.1101/2025.01.19.633671