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Article

Tyrosine phosphorylation stimulates activity of human RAD51 recombinase through altered nucleoprotein filament dynamics.

Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 2016

Subramanyam Shyamal, Ismail Mohammed, Bhattacharya Ipshita, Spies Maria

Abstract excerpt

The DNA strand exchange protein RAD51 facilitates the central step in homologous recombination, a process fundamentally important for accurate repair of damaged chromosomes, restart of collapsed replication forks, and telomere maintenance. The active form of RAD51 is a nucleoprotein filament that assembles on single-stranded DNA (ssDNA) at the sites of DNA damage. The c-Abl tyrosine kinase and its oncogenic...

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Share to DNA, Single-Stranded
Share to Homologous Recombination

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nucleoproteins

Share to Phosphotyrosine

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Share to Proto-Oncogene Proteins c-abl

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Source

Open in PubMed Open full text

Identifiers

PMID: 27671650
DOI: 10.1073/pnas.1604807113
PMCID: PMC5068273

Genes

RAD51
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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