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Article

AC220 and AraC cause differential inhibitory dynamics in patient-derived M5-AML with FLT3-ITD and, thus, ultimately distinct therapeutic outcomes.

Experimental hematology - 1 Jan 2017

An Xiaoyu, Liu Jinping, Wang Na, Wang Di, Huang Liang, Zhang Likun, Cai Jie, Wery Jean-Pierre, Zhou Demin, Zhou Jianfeng, Li Qi-Xiang

Abstract excerpt

Engrafting the bone marrow cells of a patient with M5 acute myeloid leukemia into immunocompromised mice (AM7577) resulted in serially transferrable stable AML and eventual mortality. The disease starts in the bone marrow and then expands to peripheral areas, which is typical of M5 leukemogenesis, where high leukemic burden in blood is coincident with symptoms/mortality. The leukemic cells in the mice had myeloid...

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Source

Identifiers

PMID: 27670587
DOI: 10.1016/j.exphem.2016.09.004

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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