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Article

OXPHOS mutations and neurodegeneration.

The EMBO journal - 9 Jan 2013

Koopman Werner J H, Distelmaier Felix, Smeitink Jan A M, Willems Peter H G M

Abstract excerpt

Mitochondrial oxidative phosphorylation (OXPHOS) sustains organelle function and plays a central role in cellular energy metabolism. The OXPHOS system consists of 5 multisubunit complexes (CI-CV) that are built up of 92 different structural proteins encoded by the nuclear (nDNA) and mitochondrial DNA (mtDNA). Biogenesis of a functional OXPHOS system further requires the assistance of nDNA-encoded OXPHOS assembly...

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Identifiers

PMID: 23149385
DOI: 10.1038/emboj.2012.300
PMCID: PMC3545297

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Source receipt: pubmed, retrieved 7 Sept 2026.

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