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Article

Interplay between ion binding and catalysis in the thioredoxin-coupled arsenate reductase family.

Journal of molecular biology - 21 Jul 2006

Roos Goedele, Buts Lieven, Van Belle Karolien, Brosens Elke, Geerlings Paul, Loris Remy, Wyns Lode, Messens Joris

Abstract excerpt

In the thioredoxin (Trx)-coupled arsenate reductase family, arsenate reductase from Staphylococcus aureus plasmid pI258 (Sa_ArsC) and from Bacillus subtilis (Bs_ArsC) are structurally related detoxification enzymes. Catalysis of the reduction of arsenate to arsenite involves a P-loop (Cys10Thr11Gly12Asn13Ser14Cys15Arg16) structural motif and a disulphide cascade between three conserved cysteine residues (Cys10,...

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PMID: 16797027
DOI: 10.1016/j.jmb.2006.05.054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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