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Article

The activation of electrophile, nucleophile and leaving group during the reaction catalysed by pI258 arsenate reductase.

Chembiochem : a European journal of chemical biology - 1 Jun 2006

Roos Goedele, Loverix Stefan, Brosens Elke, Van Belle Karolien, Wyns Lode, Geerlings Paul, Messens Joris

Abstract excerpt

The reduction of arsenate to arsenite by pI258 arsenate reductase (ArsC) combines a nucleophilic displacement reaction with a unique intramolecular disulfide cascade. Within this reaction mechanism, the oxidative equivalents are translocated from the active site to the surface of ArsC. The first...

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PMID: 16607668
DOI: 10.1002/cbic.200500507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16607668-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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