Back to search

Article

Investigate the regulatory effect of human IL-37 isoform a (IL-37a) on Toll-like receptor (TLR) response in vitro and in vivo

2020-01-01

Abstract excerpt

Background: Interleukin-37 is a newly discovered member of the IL-1 superfamily, consisting of 5 isoforms (IL-37a-e) due to different RNA splicing. Current studies are only focused on IL-37b isoform and demonstrate that IL-37b is an important immunosuppressive cytokine in TLR response in inflammatory diseases. However, the function and importance of other isoforms is still unknown. Here we investigate the function...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ecb6d61f-246b-5358-ba68-d5c244430815
DOI
10.5525/gla.thesis.80298
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Investigate the regulatory effect of human IL-37 isoform a (IL-37a) on Toll-like receptor (TLR) response in vitro and in vivoDOI 10.5525/gla.thesis.80298
Immunobiology of IL-37: mechanism of action and clinical perspectivesSemantic proximity
Biology of interleukin‑37 and its role in autoimmune diseases (Review)Semantic proximity
Biology of IL ‐38 and its role in diseaseSemantic proximity
The Role, Involvement and Function(s) of Interleukin-35 and Interleukin-37 in Disease PathogenesisSemantic proximity
Biology of IL-36 cytokines and their role in diseaseSemantic proximity
IL-36 cytokines in inflammatory and malignant diseases: not the new kid on the block anymoreSemantic proximity
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseasesSemantic proximity
Potential and limitations of IL-37, a cytokine targeted for therapy of systemic lupus erythematosus: A Systematic Review.Semantic proximity
Biology of interleukin-38 and its role in chronic inflammatory diseasesSemantic proximity
Aberrant Expression and Prognostic Potential of IL-37 in Human Lung AdenocarcinomaSemantic proximity
IL-12 Family Cytokines: General Characteristics, Pathogenic Microorganisms, Receptors, and Signalling PathwaysSemantic proximity
The complex roles of IL-36 and IL-38 in cancer: friends or foes?Semantic proximity
Select a neighboring publication to make it the new centre.