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Article

Potential and limitations of IL-37, a cytokine targeted for therapy of systemic lupus erythematosus: A Systematic Review.

International immunopharmacology - 10 Jan 2025

Mohamed Thaha Ummul Aqeela Balqees, Wan Mohamad Wan Majdiah, Nik Husain Nik Rosmawati, Yusop Norhayati, Mohamud Rohimah, Wan Ghazali Wan Syamimee

Abstract excerpt

BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by dysregulated immune responses and inflammation. Interleukin-37 (IL-37) is a recently discovered immunomodulatory cytokine with potential anti-inflammatory properties. This systematic review explores the relationship between IL and 37 and SLE disease activity, and evaluates its potential as a therapeutic agent. METHODS:...

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PMID: 39566387
DOI: 10.1016/j.intimp.2024.113597

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