Article
MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells.
Blood - 10 Nov 2016
Sheikh Bilal N, Yang Yuqing, Schreuder Jaring, Nilsson Susan K, Bilardi Rebecca, Carotta Sebastian, McRae Helen M, Metcalf Donald, Voss Anne K, Thomas Tim
Abstract excerpt
Hematopoietic stem cells (HSCs) are conventionally thought to be at the apex of a hierarchy that produces all mature cells of the blood. The quintessential property of these cells is their ability to reconstitute the entire hematopoietic system of hemoablated recipients. This characteristic has enabled HSCs to be used to replenish the hematopoietic system of patients after chemotherapy or radiotherapy. Here, we...
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