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Article

Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT-mTOR-S6K signaling and drug responses.

Journal of cell science - 1 Jan 2017

Riedl Angelika, Schlederer Michaela, Pudelko Karoline, Stadler Mira, Walter Stefanie, Unterleuthner Daniela, Unger Christine, Kramer Nina, Hengstschläger Markus, Kenner Lukas, Pfeiffer Dagmar, Krupitza Georg, Dolznig Helmut

Abstract excerpt

Three-dimensional (3D) cancer models are used as preclinical systems to mimic physiologic drug responses. We provide evidence for strong changes of proliferation and metabolic capacity in three dimensions by systematically analyzing spheroids of colon cancer cell lines. Spheroids showed relative lower activities in the AKT, mammalian target of rapamycin (mTOR) and S6K (also known as RPS6KB1) signaling pathway...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27663511
DOI: 10.1242/jcs.188102

Genes

RPS6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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