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Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors

19 Apr 2010

Abstract excerpt

Predicting drug response in cancer patients remains a major challenge in the clinic. We have perfected an ex vivo, reproducible, rapid and personalized culture method to investigate antitumoral pharmacological properties that preserves the original cancer microenvironment. Response to signal transduction inhibitors in cancer is determined not only by properties of the drug target but also by mutations in other...

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PMID: 20404174
DOI: 10.1073/pnas.0907676107

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