Article
Spinal column chordoma: prognostic significance of clinical variables and T (brachyury) gene SNP rs2305089 for local recurrence and overall survival.
Neuro-oncology - 1 Mar 2017
Bettegowda Chetan, Yip Stephen, Lo Sheng-Fu Larry, Fisher Charles G, Boriani Stefano, Rhines Laurence D, Wang Joanna Y, Lazary Aron, Gambarotti Marco, Wang Wei-Lien, Luzzati Alessandro, Dekutoski Mark B, Bilsky Mark H, Chou Dean, Fehlings Michael G, McCarthy Edward F, Quraishi Nasir A, Reynolds Jeremy J, Sciubba Daniel M, Williams Richard P, Wolinsky Jean-Paul, Zadnik Patricia L, Zhang Ming, Germscheid Niccole M, Kalampoki Vasiliki, Varga Peter Pal, Gokaslan Ziya L
Abstract excerpt
Background: Chordomas are rare, locally aggressive bony tumors associated with poor outcomes. Recently, the single nucleotide polymorphism (SNP) rs2305089 in the T (brachyury) gene was strongly associated with sporadic chordoma development, but its clinical utility is undetermined. Methods: In 333 patients with spinal chordomas, we identified prognostic factors for local recurrence-free survival (LRFS) and...
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