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Article

Gastrointestinal stromal tumors (GISTs) and second malignancies: A novel "sentinel tumor"? A monoinstitutional, STROBE-compliant observational analysis.

Medicine - 1 Sept 2016

Rodriquenz Maria Grazia, Rossi Sabrina, Ricci Riccardo, Martini Maurizio, Larocca Mario, Dipasquale Angelo, Quirino Michela, Schinzari Giovanni, Basso Michele, D'Argento Ettore, Strippoli Antonia, Barone Carlo, Cassano Alessandra

Abstract excerpt

Several evidences showed that patients with gastrointestinal stromal tumors (GISTs) develop additional malignancies. However, thorough incidence of second tumors remains uncertain as the possibility of a common molecular pathogenesis.A retrospective series of 128 patients with histologically proven GIST treated at our institution was evaluated. Molecular analysis of KIT and PDGFR-α genes was performed in all...

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Identifiers

PMID: 27661019
DOI: 10.1097/MD.0000000000004718
PMCID: PMC5044889

Genes

KRAS
KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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