Gastrointestinal Stromal Tumors: A Review of Case Reports, Diagnosis, Treatment, and Future Directions

Abstract excerpt

Gastrointestinal stromal tumor (GIST) is a nonepithelial, mesenchymal tumor first described by Mazur and Clark in 1983. Since then, its molecular biology has been studied in great detail. Special interest in the role of tyrosine kinase in its regulation has been the target by different drug research. Mutation in c-kit exons 9, 11, 13, 17 and PDGFRA mutation in exons 12, 14, 18 are responsible for activation of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gastric Cancer Management and Outcomes
• Share to Gastrointestinal Tumor Research and Treatment
• Share to Sarcoma Diagnosis and Treatment