Article
Gastrointestinal Stromal Tumor With Multiple Primary Tyrosine Kinase Mutations-Clinicopathologic and Molecular Characterization.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Jul 2019
Wong Newton A C S, Taniere Philippe, Walsh Shaun, Wallace Andrew, Nonaka Daisuke, Jones Thomas, Gonzalez David
Abstract excerpt
A unique cohort of chemo-naive gastrointestinal stromal tumors (GISTs) with double-primary tyrosine kinase mutations was characterized particularly to determine whether coexistent mutations represent a single mutational event. Up to 2013, 4 UK centers reported 9 GISTs with 2 primary tyrosine kinase mutations. In each of 8 cases validated by next generation sequencing, both mutations were present in the same...
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