Article
Osteocyte-Secreted Wnt Signaling Inhibitor Sclerostin Contributes to Beige Adipogenesis in Peripheral Fat Depots.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 2017
Fulzele Keertik, Lai Forest, Dedic Christopher, Saini Vaibhav, Uda Yuhei, Shi Chao, Tuck Padrig, Aronson Jenna L, Liu Xiaolong, Spatz Jordan M, Wein Marc N, Divieti Pajevic Paola
Abstract excerpt
Cells of the osteoblast lineage are increasingly identified as participants in whole-body metabolism by primarily targeting pancreatic insulin secretion or consuming energy. Osteocytes, the most abundant bone cells, secrete a Wnt-signaling inhibitor called sclerostin. Here we examined three mouse models expressing high sclerostin levels, achieved through constitutive or inducible loss of the stimulatory subunit...
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