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Sclerostin: clinical insights in muscle–bone crosstalk

1 Aug 2023

Abstract excerpt

) gene, is mostly expressed in osteocytes. First described in the pathogenesis of three disorders, sclerosteosis, van Buchem's disease, and craniodiaphyseal dysplasia, sclerostin has been identified as an important regulator of bone homeostasis, controlling bone formation by osteoblasts through inhibition of the canonical Wnt signaling pathway. Recent studies have highlighted a hypothetical role of sclerostin in...

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PMID: 37632438
DOI: 10.1177/03000605231193293

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