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Article

TNF-α gene polymorphisms and expression

7 Sept 2016

Abstract excerpt

Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine with an important role in the pathogenesis of several diseases. Its encoding gene is located in the short arm of chromosome 6 in the major histocompatibility complex class III region. Most of the TNF-α gene polymorphisms are located in its promoter region and they are thought to affect the susceptibility and/or severity of different human diseases....

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PMID: 27652081
DOI: 10.1186/s40064-016-3197-y

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