Article
Whole exome sequencing of wild-derived inbred strains of mice improves power to link phenotype and genotype.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Oct 2017
Chang Peter L, Kopania Emily, Keeble Sara, Sarver Brice A J, Larson Erica, Orth Annie, Belkhir Khalid, Boursot Pierre, Bonhomme François, Good Jeffrey M, Dean Matthew D
Abstract excerpt
The house mouse is a powerful model to dissect the genetic basis of phenotypic variation, and serves as a model to study human diseases. Despite a wealth of discoveries, most classical laboratory strains have captured only a small fraction of genetic variation known to segregate in their wild progenitors, and existing strains are often related to each other in complex ways. Inbred strains of mice independently...
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