Impact of a Genetic Risk Score on Myocardial Infarction Risk Across Different Ethnic Populations.

doi:10.1016/j.cjca.2016.05.014

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Article

Impact of a Genetic Risk Score on Myocardial Infarction Risk Across Different Ethnic Populations.

The Canadian journal of cardiology - 1 Dec 2016

Joseph Philip G, Pare Guillaume, Asma Senay, Engert James C, Yusuf Salim, Anand Sonia S

Abstract excerpt

BACKGROUND: Myocardial infarction (MI) risk varies by ethnicity, although the influence of genetic factors remains unclear. Using a genetic risk score (GRS), we examined the association between 25 coronary artery disease (CAD)-related single nucleotide polymorphisms and MI across 6 ethnic groups. METHODS: We studied 8556 participants in the INTERHEART case-control study from 6 ethnic groups: Europeans, South...

Topics

Case-Control Studies
Effect Modifier, Epidemiologic
Ethnicity
Female
Gene Frequency
Genetic Markers
Genetic Predisposition to Disease
Genetic Testing
Genome-Wide Association Study
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Myocardial Infarction

Polymorphism, Single Nucleotide

Predictive Value of Tests

Research Design

Risk Factors

Source

Open in PubMed

Identifiers

PMID: 27650930
DOI: 10.1016/j.cjca.2016.05.014

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