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Article

Association between a literature-based genetic risk score and cardiovascular events in women.

JAMA - 17 Feb 2010

Paynter Nina P, Chasman Daniel I, Paré Guillaume, Buring Julie E, Cook Nancy R, Miletich Joseph P, Ridker Paul M

Abstract excerpt

CONTEXT: While multiple genetic markers associated with cardiovascular disease have been identified by genome-wide association studies, their aggregate effect on risk beyond traditional factors is uncertain, particularly among women. OBJECTIVE: To test the predictive ability of a literature-based genetic risk score for cardiovascular disease. DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort of 19,313...

Topics

Alleles
Cardiovascular Diseases
Female
Genetic Markers
Genetic Predisposition to Disease
Humans
Middle Aged
Phenotype
Polymorphism, Single Nucleotide
Prospective Studies
Risk

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Identifiers

PMID: 20159871
DOI: 10.1001/jama.2010.119
PMCID: PMC2845522

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