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Article

Energy balance-related factors and risk of colorectal cancer based on KRAS, PIK3CA, and BRAF mutations and MMR status.

Journal of cancer research and clinical oncology - 1 Oct 2022

Jenniskens Josien C A, Offermans Kelly, Simons Colinda C J M, Samarska Iryna, Fazzi Gregorio E, van der Meer Jaleesa R M, Smits Kim M, Schouten Leo J, Weijenberg Matty P, Grabsch Heike I, van den Brandt Piet A

Abstract excerpt

INTRODUCTION: KRAS mutations (KRASmut), PIK3CAmut, BRAFmut, and mismatch repair deficiency (dMMR) have been associated with the Warburg-effect. We previously observed differential associations between energy balance-related factors (BMI, clothing-size, physical activity) and colorectal cancer (CRC) subtypes based on the Warburg-effect. We now investigated whether associations between energy balance-related...

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PMID: 35546360
DOI: 10.1007/s00432-022-04019-9
PMCID: PMC9470639

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