Article
Identification of Claudin 1 Transcript Variants in Human Invasive Breast Cancer.
PloS one - 1 Jan 2016
Blanchard Anne A, Zelinski Teresa, Xie Jiuyong, Cooper Steven, Penner Carla, Leygue Etienne, Myal Yvonne
Abstract excerpt
BACKGROUND: The claudin 1 tight junction protein, solely responsible for the barrier function of epithelial cells, is frequently down regulated in invasive human breast cancer. The underlying mechanism is largely unknown, and no obvious mutations in the claudin 1 gene (CLDN1) have been identified to date in breast cancer. Since many genes have been shown to undergo deregulation through splicing and mis-splicing...
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