Two common human CLDN5 alleles encode different open reading frames but produce one protein isoform.

doi:10.1111/nyas.13342

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Article

Two common human CLDN5 alleles encode different open reading frames but produce one protein isoform.

Annals of the New York Academy of Sciences - 1 Jun 2017

Cornely Ronald M, Schlingmann Barbara, Shepherd Whitney S, Chandler Joshua D, Neujahr David C, Koval Michael

Abstract excerpt

Claudins provide tight junction barrier selectivity. The human CLDN5 gene contains a high-frequency single-nucleotide polymorphism (rs885985), where the G allele codes for glutamine (Q) and the A allele codes for an amber stop codon. Thus, these different CLDN5 alleles define nested open reading frames (ORFs) encoding claudin-5 proteins that are 303 or 218 amino acids in length. Interestingly, human claudin-16...

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PMID: 28445614
DOI: 10.1111/nyas.13342
PMCID: PMC5479753

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CLDN5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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