Article
A new functional IDH2 genetic variant is associated with the risk of lung cancer.
Molecular carcinogenesis - 1 Mar 2017
Li Jiangjiang, Lu Jingchen, He Ya, Wu Yong, Wu Yuan, Song Xin, Jiang Yuee, Tang Min, Weng Xinxian, Yi Wei, Luo Xiangjian, Sun Lunquan, Bode Ann M, Cao Ya
Abstract excerpt
Recently, mutations in isocitrate dehydrogenase 1/2 (IDH1/2) were discovered in 70% of low-grade glioma and secondary glioblastoma multiforme. The discovery of an oncogenic function and the identification of onco-metabolites of IDH1/2 support new roles for metabolism in cancer. For example, some evidence indicates that IDH2 might also exhibit oncogenic functions by promoting cellular metabolism and cancer cell...
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