Article
Familial hematological malignancies: new IDH2 mutation.
Annals of hematology - 1 Dec 2016
Hamadou Walid-Sabri, Bourdon Violaine, Létard Sébastien, Brenet Fabienne, Laarif Sofien, Besbes Sawsen, Paci Angelo, David Muriel, Penard-Lacronique Virginie, Youssef Yosra Ben, Laatiri Mohamed-Adnène, Eisinger François, Mari Véronique, Gesta Paul, Dreyfus Hélène, Bonadona Valérie, Dugast Catherine, Zattara Hélène, Faivre Laurence, Noguchi Testsuro, Khélif Abderrahim, Salem Chaker Ben, Dubreuil Patrice, Sobol Hagay, Soua Zohra
Abstract excerpt
Isocitrate dehydrogenase IDH 1 and IDH 2 mutations were reported in several cancer forms, especially in hematological malignancies, but were never been investigated in familial aggregation. The aim of this study is to determine whether germline isocitrate dehydrogenase genes mutations are involved.We targeted IDH1 and IDH2 genes in 104 familial cases belonging to Tunisian and French populations, including several...
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