Whole-exome sequencing and targeted gene sequencing provide insights into the role of PALB2 as a male breast cancer susceptibility gene.

doi:10.1002/cncr.30337

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Whole-exome sequencing and targeted gene sequencing provide insights into the role of PALB2 as a male breast cancer susceptibility gene.

Cancer - 1 Jan 2017

Silvestri Valentina, Zelli Veronica, Valentini Virginia, Rizzolo Piera, Navazio Anna Sara, Coppa Anna, Agata Simona, Oliani Cristina, Barana Daniela, Castrignanò Tiziana, Viel Alessandra, Russo Antonio, Tibiletti Maria Grazia, Zanna Ines, Masala Giovanna, Cortesi Laura, Manoukian Siranoush, Azzollini Jacopo, Peissel Bernard, Bonanni Bernardo, Peterlongo Paolo, Radice Paolo, Palli Domenico, Giannini Giuseppe, Chillemi Giovanni, Montagna Marco, Ottini Laura

Abstract excerpt

BACKGROUND: Male breast cancer (MBC) is a rare disease whose etiology appears to be largely associated with genetic factors. BRCA1 and BRCA2 mutations account for about 10% of all MBC cases. Thus, a fraction of MBC cases are expected to be due to genetic factors not yet identified. To further explain the genetic susceptibility for MBC, whole-exome sequencing (WES) and targeted gene sequencing were applied to...

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Identifiers

PMID: 27648926
DOI: 10.1002/cncr.30337

Genes

BRCA1
PALB2
BRCA2
NAT1

Variants

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Whole-exome sequencing and targeted gene sequencing provide insights into the role of PALB2 as a male breast cancer susceptibility gene.PMID 27648926Read ↗

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