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Article

Role of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIV.

PloS one - 1 Jan 2016

Narendran Gopalan, Kavitha Dhanasekaran, Karunaianantham Ramesh, Gil-Santana Leonardo, Almeida-Junior Jilson L, Reddy Sirasanambatti Devarajulu, Kumar Marimuthu Makesh, Hemalatha Haribabu, Jayanthi Nagesh Nalini, Ravichandran Narayanan, Krishnaraja Raja, Prabhakar Angamuthu, Manoharan Tamizhselvan, Nithyananthan Lokeswaran, Arjunan Gunasundari, Natrajan Mohan, Swaminathan Soumya, Andrade Bruno B

Abstract excerpt

BACKGROUND: Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an inflammatory phenomenon complicating HIV management in coincidental tuberculosis (TB) infection, upon immune reconstitution driven by antiretroviral therapy (ART). Leukotriene A4 hydroxylase (LTA4H), an enzyme which converts LTA4 to LTB4, regulates the balance between the anti-inflammatory lipoxins and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27643598
DOI: 10.1371/journal.pone.0163298
PMCID: PMC5028072

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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