Article
FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy.
The Journal of clinical investigation - 3 Oct 2016
Lexmond Willem S, Goettel Jeremy A, Lyons Jonathan J, Jacobse Justin, Deken Marion M, Lawrence Monica G, DiMaggio Thomas H, Kotlarz Daniel, Garabedian Elizabeth, Sackstein Paul, Nelson Celeste C, Jones Nina, Stone Kelly D, Candotti Fabio, Rings Edmond H H M, Thrasher Adrian J, Milner Joshua D, Snapper Scott B, Fiebiger Edda
Abstract excerpt
In addition to the infectious consequences of immunodeficiency, patients with Wiskott-Aldrich syndrome (WAS) often suffer from poorly understood exaggerated immune responses that result in autoimmunity and elevated levels of serum IgE. Here, we have shown that WAS patients and mice deficient in WAS protein (WASP) frequently develop IgE-mediated reactions to common food allergens. WASP-deficient animals displayed...
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