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Article

Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis.

The Journal of clinical investigation - 1 Feb 2007

Humblet-Baron Stephanie, Sather Blythe, Anover Stephanie, Becker-Herman Shirly, Kasprowicz Debora J, Khim Socheath, Nguyen Thuc, Hudkins-Loya Kelly, Alpers Charles E, Ziegler Steve F, Ochs Hans, Torgerson Troy, Campbell Daniel J, Rawlings David J

Abstract excerpt

Wiskott-Aldrich syndrome protein (WASp) is essential for optimal T cell activation. Patients with WAS exhibit both immunodeficiency and a marked susceptibility to systemic autoimmunity. We investigated whether alterations in Treg function might explain these paradoxical observations. While WASp-deficient (WASp(-/-)) mice exhibited normal thymic Treg generation, the competitive fitness of peripheral Tregs was...

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Identifiers

PMID: 17218989
DOI: 10.1172/JCI29539
PMCID: PMC1764857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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