Article
Spontaneous food allergy in Was-/- mice occurs independent of FcεRI-mediated mast cell activation.
Allergy - 1 Dec 2017
Lexmond W S, Goettel J A, Sallis B F, McCann K, Rings E H H M, Jensen-Jarolim E, Nurko S, Snapper S B, Fiebiger E
Abstract excerpt
BACKGROUND: Food allergies are a growing health problem, and the development of therapies that prevent disease onset is limited by the lack of adjuvant-free experimental animal models. We compared allergic sensitization in patients with food allergy or Wiskott-Aldrich syndrome (WAS) and defined whether spontaneous disease in Was-/- mice recapitulates the pathology of a conventional disease model and/or human food...
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