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Article

Controlled WASp activity regulates the proliferative response for Treg cell differentiation in the thymus.

European journal of immunology - 1 May 2024

Vasconcelos-Fontes Larissa, Vieira Rhaissa C, He Minghui, Ferreira-Reis Rafaella, Jurberg Arnon Dias, Arêas Mendes-da-Cruz Daniella, Andersson John, Cotta-de-Almeida Vinicius, Westerberg Lisa S

Abstract excerpt

The Wiskott-Aldrich syndrome protein (WASp) regulates actin cytoskeletal dynamics and function of hematopoietic cells. Mutations in the WAS gene lead to two different syndromes; Wiskott-Aldrich syndrome (WAS) caused by loss-of-function mutations, and X-linked neutropenia (XLN) caused by gain-of-function mutations. We previously showed that WASp-deficient mice have a decreased number of regulatory T (Treg) cells...

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Identifiers

PMID: 38356202
DOI: 10.1002/eji.202350450

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CD4

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