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Article

Endosialin-Expressing Pericytes Promote Metastatic Dissemination

15 Sept 2016

Abstract excerpt

Metastasis is a multistep process that is critically dependent on the interaction of metastasizing tumor cells with cells in the local microenvironment. Within this tumor stroma, vessel-associated pericytes and myofibroblasts share a number of traits, including the upregulated expression of the transmembrane receptor endosialin (CD248). Comparative experiments in wild-type and endosialin-deficient mice revealed...

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PMID: 27635044
DOI: 10.1158/0008-5472.can-16-0932

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