Article
Key roles of CD4+ T cells and IFN-gamma in the development of abdominal aortic aneurysms in a murine model.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2004
Xiong Wanfen, Zhao Yong, Prall Amy, Greiner Timothy C, Baxter B Timothy
Abstract excerpt
Abdominal aortic aneurysm (AAA) is one of a number of diseases associated with a prominent inflammatory cell infiltrate and local destruction of structural matrix macromolecules. This inflammatory infiltrate is predominately composed of T lymphocytes and macrophages. Delineating specific contribution of these inflammatory cells and their cytokines in AAA formation is the key to understanding AAA and other chronic...
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