Article
Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study.
Scientific reports - 16 Sept 2016
Santoro Anna Maria, Monaco Irene, Attanasio Francesco, Lanza Valeria, Pappalardo Giuseppe, Tomasello Marianna Flora, Cunsolo Alessandra, Rizzarelli Enrico, De Luigi Ada, Salmona Mario, Milardi Danilo
Abstract excerpt
Due to their altered metabolism cancer cells are more sensitive to proteasome inhibition or changes of copper levels than normal cells. Thus, the development of copper complexes endowed with proteasome inhibition features has emerged as a promising anticancer strategy. However, limited information is available about the exact mechanism by which copper inhibits proteasome. Here we show that Cu(II) ions...
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