Article
Tbx3 fosters pancreatic cancer growth by increased angiogenesis and activin/nodal-dependent induction of stemness.
Stem cell research - 1 Sept 2016
Perkhofer Lukas, Walter Karolin, Costa Ivan G, Carrasco Maria C Romero, Eiseler Tim, Hafner Susanne, Genze Felicitas, Zenke Martin, Bergmann Wendy, Illing Anett, Hohwieler Meike, Köhntop Ralf, Lin Qiong, Holzmann Karl-Heinz, Seufferlein Thomas, Wagner Martin, Liebau Stefan, Hermann Patrick C, Kleger Alexander, Müller Martin
Abstract excerpt
Cell fate decisions and pluripotency, but also malignancy depend on networks of key transcriptional regulators. The T-box transcription factor TBX3 has been implicated in the regulation of embryonic stem cell self-renewal and cardiogenesis. We have recently discovered that forced TBX3 expression in embryonic stem cells promotes mesendoderm specification directly by activating key lineage specification factors and...
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