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Article

An experimental phylogeny to benchmark ancestral sequence reconstruction.

Nature communications - 15 Sept 2016

Randall Ryan N, Radford Caelan E, Roof Kelsey A, Natarajan Divya K, Gaucher Eric A

Abstract excerpt

Ancestral sequence reconstruction (ASR) is a still-burgeoning method that has revealed many key mechanisms of molecular evolution. One criticism of the approach is an inability to validate its algorithms within a biological context as opposed to a computer simulation. Here we build an experimental phylogeny using the gene of a single red fluorescent protein to address this criticism. The evolved phylogeny...

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Identifiers

PMID: 27628687
DOI: 10.1038/ncomms12847
PMCID: PMC5027606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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