Article
Association of the IGF1 gene with fasting insulin levels.
European journal of human genetics : EJHG - 1 Aug 2016
Willems Sara M, Cornes Belinda K, Brody Jennifer A, Morrison Alanna C, Lipovich Leonard, Dauriz Marco, Chen Yuning, Liu Ching-Ti, Rybin Denis V, Gibbs Richard A, Muzny Donna, Pankow James S, Psaty Bruce M, Boerwinkle Eric, Rotter Jerome I, Siscovick David S, Vasan Ramachandran S, Kaplan Robert C, Isaacs Aaron, Dupuis Josée, van Duijn Cornelia M, Meigs James B
Abstract excerpt
Insulin-like growth factor 1 (IGF-I) has been associated with insulin resistance. Genome-wide association studies (GWASs) of fasting insulin (FI) identified single-nucleotide variants (SNVs) near the IGF1 gene, raising two hypotheses: (1) these associations are mediated by IGF-I levels and (2) these noncoding variants either tag other functional variants in the region or are directly functional. In our study,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.