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Article

Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome.

American journal of physiology. Heart and circulatory physiology - 1 May 2006

Davies Joanna K, Wells Dominic J, Liu Ke, Whitrow Helen R, Daniel Tyrone D, Grignani Robert, Lygate Craig A, Schneider Jürgen E, Noël Gaëtane, Watkins Hugh, Carling David

Abstract excerpt

AMP-activated protein kinase (AMPK) is the downstream component of a protein kinase cascade that plays a key role in the regulation of energy metabolism. In humans, mutations in the gamma2-subunit of AMPK cause cardiac hypertrophy associated with Wolff-Parkinson-White syndrome, characterized by ventricular preexcitation. The effect of these mutations on AMPK activity and in development of the disease is...

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Identifiers

PMID: 16339829
DOI: 10.1152/ajpheart.01020.2005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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